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Two otherwise healthy immunocompetent men,ages 62 and 66 years,experienced years of radicular pain without zoster rash.An extensive search for systemic disease and malignancy was negative.Varicella-zoster virus DNA, but not herpes simplex virus DNA,was found in the cerebrospinal fluid of the first patient 5 months after the onset of the pain,and in the second patient 8 months after the onset of the pain.Prolonged radicular pain without zoster rash combined with the presence of varicella-zoster virus in the cerebrospinal fluid indicates that both men had zoster sine herpete,and strongly supports this syndrome as a clinical variant. |
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